Copper and the Skin by Jurij J. Hostynek, Howard I. Maibach

By Jurij J. Hostynek, Howard I. Maibach

Copper is more and more famous for its attainable position within the prevention and moderation of sickness, in addition to the therapy of a few stipulations together with epidermis inflammation, sensitization, rheumatoid arthritis, and different inflammatory stipulations. This resource stories normal rules of percutaneous penetration to explain the mechanisms controlling anti inflammatory task, dermal sensitivity, and the absorption of copper compounds within the human physique and the consequences of those features on fit epidermis and human healthiness.

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Extra resources for Copper and the Skin

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Thanks to these modeling efforts, it is now possible to predict diffusion of nonelectrolytes through the skin as a model membrane with some accuracy, simply based on a few physicochemical parameters that characterize the permeant. Such models are useful in predicting the activity of chemicals in the absence of experimental data on a particular compound, without the need for its actual synthesis. Set in relation to the corresponding in vivo data, the predictive power of these models, known as quantitative structure–activity relationships (or QSAR), demonstrates that (i) three descriptors (size, polarity, and hydrogen bonding) are the principal determinants for cutaneous transport, and (ii) the properties of the intercellular SC lipids alone are sufficient to characterize the barrier properties of the skin as the route of permeation for that category of chemical structures (32).

Contamination by nickel, copper and zinc during the handling of Euro coins. Contact Dermatitis 2003; 48:181–8. 22. Lachapelle J-M, Marot L. High nickel release from 1- and 2-Euro coins: are there practical implications? Dermatology 2004; 209:288–290. 23. Oster GK. Chemical reactions of the copper intrauterine device. Fertil Steril 1972; 23:18–23. 18 Hostynek 24. Sekelj P, Rasmussen K, McDougall D, Baggs J. Survey of electrolytes of unstimulated sweat from the hand in normal and diseased adults.

The new EURO releases nickel and elicits contact eczema. Br J Dermatol 2002; 146:155–6. 20. Nestle FO, Speidel H, Speidel MO. High nickel release from 1- and 2-Euro coins. Nature 2002; 419:419. 21. Fournier P-G, Govers TR. Contamination by nickel, copper and zinc during the handling of Euro coins. Contact Dermatitis 2003; 48:181–8. 22. Lachapelle J-M, Marot L. High nickel release from 1- and 2-Euro coins: are there practical implications? Dermatology 2004; 209:288–290. 23. Oster GK. Chemical reactions of the copper intrauterine device.

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