By J. L. Leveque, P. Corcuff (auth.), Prof. Dr. med. Peter J. Frosch, Albert M. Kligman M.D. (eds.)
More than 10 years in the past, I had the opportunity to go to the collage health facility in Munster, Germany. on the outpatient health center there, I accidently met a tender dermatologist who used to be dedicated to the examine of the quantification of aggravated dermis in the course of his busy day-by-day scientific paintings. I sensed instantly that this Dr. P. Frosch used to be engaging in his examine with the beliefs and exuberance which have been so well-known to me. quickly we chanced on that we shared an analogous earlier event; we either had all started our careers in dermatological research with an identical mentor. For me it was once greater than 25 years in the past that I first met Dr. Kligman, Professor on the college of Pennsylvania in Philadelphia, united states. I reminisced that I have been tremendously stunned through his preliminary query ''As a dermatologist, do you need to check dwelling or lifeless skin?" simply because, at the moment or even at the present time, at any time when we can't acquire adequate information regarding the surface with the bare eye, it truly is invasively got rid of is usual perform to histologically study a pores and skin pattern that from dwelling tissue. Many dermatologists nonetheless might by no means examine learning the residing intact epidermis itself noninvasively via current complex applied sciences to evaluate its structural and practical homes. at the moment Dr. Kligman meant to accumulate a procedure of comparing the outside from a variety of points, utilizing equipment that were unduly ignored some time past and introducing a variety of technological instruments.
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Extra resources for Noninvasive Methods for the Quantification of Skin Functions: An Update on Methodology and Clinical Applications
The equipment de- 50 A. Triebskom and M. Gloor scribed by Tagami et al. 5 MHz. It functions with dry electrodes and has the asset that both impedance and capacitance measurements are possible. In earlier investigations, Tagami et al.  described that with this apparatus the hydration of the most superficial layers of the stratum corneum is determined. The more recent investigations of Obata and Tagami  with this instrument - which has meanwhile been provided with a new more sensitive probe - on a simulation model of stratum corneum have shown that skin conductance did not only correlate very well with the water content in the superficial layer of the simulation model, but also with the water content of the stratum corneum model as a whole.
The energy of the stochastic component (Es) behaves anisotropically in the untreated condition (with a minimum at CjJ = 90°; in the treated condition, Ep is practically isotropic. This means that the periodic component of the skin's surface is more strongly affected by a treatment than is the stochastic component. With E , the effects of treatment are maximal p at CjJ = 90° and minimal at CjJ = 0°. The opposite relationships hold true for Es' In other words, we find that a treatment leads to a reduction of the periodic structures.
16) Dermatological disorders lead to obvious changes in the skin microrelief. As mentioned earlier, the cutaneous relief mainly depends on the spatial organization of collagen bundles. This relief can be observed at the dermoepidermal junction. Among Fig. 18. Cutis rhomboidalis nucchae, a Overview; b Detail of the square area in a; c SEM of the rectangle in bArrow indicates a normal starshaped skin surrounded by elastoticlike patterns . (Courtesy of Dr O . lSb c the different pathologies those originating from the dermis should be focused on.